Cerberus
Cerberus is a term that originates from Greek mythology, but in the context of medicine, it refers to a protein that in humans is encoded by the CER1 gene. This protein is known to play a crucial role in embryonic development, particularly in the formation of the anterior-posterior (head-tail) body axis.
Function[edit | edit source]
Cerberus is a secreted protein that functions as a bone morphogenetic protein (BMP) inhibitor. It is involved in the embryogenesis and morphogenesis of certain body parts. It acts by binding to BMPs and preventing them from interacting with their receptors. This is crucial in the formation of the head and other anterior structures during embryonic development.
Clinical Significance[edit | edit source]
Mutations in the CER1 gene have been associated with several medical conditions. For instance, they have been linked to left-right axis malformations, which can result in conditions such as situs inversus and heterotaxy.
Research[edit | edit source]
Research into the CER1 gene and the Cerberus protein is ongoing, with scientists seeking to understand more about their roles in human development and disease. This research could potentially lead to new treatments for a range of conditions.
See Also[edit | edit source]
References[edit | edit source]
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Contributors: Prab R. Tumpati, MD