Cercopithecine gammaherpesvirus 14
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Cercopithecine gammaherpesvirus 14 (CeHV-14) is a member of the Herpesviridae family, specifically classified under the subfamily Gammaherpesvirinae. This virus is part of the genus Rhadinovirus and is known to infect non-human primates, particularly those belonging to the Cercopithecidae family, which includes various species of Old World monkeys.
Virology[edit | edit source]
Cercopithecine gammaherpesvirus 14 is a double-stranded DNA virus, characteristic of the Herpesviridae family. Like other gammaherpesviruses, CeHV-14 establishes latent infections in its host, primarily targeting lymphoid tissues. During latency, the viral genome persists in the host cells without producing infectious virions, allowing the virus to evade the host's immune system.
The virus can reactivate under certain conditions, leading to the production of new virions and potential transmission to other hosts. The mechanisms of latency and reactivation are areas of active research, as they are crucial for understanding the pathogenesis of gammaherpesviruses.
Pathogenesis[edit | edit source]
The pathogenic potential of CeHV-14 in its natural hosts is not fully understood. However, gammaherpesviruses are generally associated with lymphoproliferative diseases and can contribute to the development of certain cancers in their hosts. In non-human primates, CeHV-14 may cause similar conditions, although specific disease associations have yet to be conclusively identified.
Transmission[edit | edit source]
Transmission of CeHV-14 is believed to occur through close contact between infected and susceptible hosts, similar to other herpesviruses. The virus can be shed in bodily fluids, facilitating its spread within social groups of primates.
Research and Importance[edit | edit source]
Studying CeHV-14 provides insights into the biology of gammaherpesviruses and their interactions with the host immune system. Understanding these interactions is crucial for developing strategies to prevent and treat diseases caused by related viruses in humans, such as Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus.
Also see[edit | edit source]
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