Chemical library
Chemical Library
A chemical library or compound library is a collection of stored chemicals that are organized to facilitate the systematic screening of large numbers of chemicals to discover their ability to modulate biological activity. These libraries are used in high-throughput screening for drug discovery, chemical biology studies, and agricultural research.
Overview[edit | edit source]
Chemical libraries can be divided into two main types: natural product libraries and synthetic libraries. Natural product libraries are derived from natural sources such as plants, animals, and microorganisms, while synthetic libraries are created through chemical synthesis.
Natural Product Libraries[edit | edit source]
Natural product libraries are collections of compounds isolated from natural sources. These libraries are often used in drug discovery due to the structural diversity and biological activity of natural products. The process of creating a natural product library involves the collection of samples, extraction of compounds, and purification and identification of the active compounds.
Synthetic Libraries[edit | edit source]
Synthetic libraries are created through chemical synthesis. These libraries can be designed to target specific biological pathways or diseases. The process of creating a synthetic library involves the design and synthesis of compounds, followed by their purification and characterization.
Applications[edit | edit source]
Chemical libraries are primarily used in drug discovery and development. They are used in high-throughput screening to identify compounds that have a desired biological activity. These compounds can then be further optimized and developed into drugs. Chemical libraries are also used in chemical biology research to study the interaction of small molecules with biological systems.
Challenges[edit | edit source]
Despite their utility, chemical libraries also present several challenges. These include the need for high-quality compounds, the difficulty of synthesizing complex molecules, and the need for efficient screening methods.
See Also[edit | edit source]
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Contributors: Prab R. Tumpati, MD
