Chlormethiazole

Chlormethiazole (also known as clomethiazole) is a sedative and hypnotic drug that is classified as a thiazole derivative. It is primarily used in the treatment of alcohol withdrawal and is also used in the management of certain types of epilepsy.

Pharmacology

Chlormethiazole acts as a GABA agonist, which means it increases the activity of the GABA neurotransmitter in the brain. This results in a decrease in neuronal excitability, which can help to reduce symptoms of alcohol withdrawal and prevent seizures in certain types of epilepsy.

Medical uses

Chlormethiazole is primarily used in the treatment of alcohol withdrawal. It can help to reduce the severity of withdrawal symptoms and prevent complications such as seizures and delirium tremens. It is also used in the management of certain types of epilepsy, particularly those that are not well controlled by other medications.

Side effects

Common side effects of chlormethiazole include drowsiness, dizziness, and confusion. Less common side effects can include nausea, vomiting, and skin rash. In rare cases, chlormethiazole can cause serious side effects such as respiratory depression and liver damage.

Contraindications

Chlormethiazole should not be used in people with known hypersensitivity to the drug or any of its components. It should also be used with caution in people with liver disease, as it can potentially cause liver damage.

See also

• Alcohol withdrawal syndrome
• Epilepsy
• GABA

Chlormethiazole Resources
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