Choline tetrathiomolybdate

Choline tetrathiomolybdate is a drug used in the treatment of Wilson's disease, a rare inherited disorder that causes copper to accumulate in the body's organs. It is a type of chelating agent, which means it binds to copper and helps remove it from the body.

Mechanism of action

Choline tetrathiomolybdate works by forming a stable tripartite complex with copper and protein, preventing the absorption of copper in the intestine and promoting its excretion from the body. This reduces the amount of copper available for absorption and helps to prevent further accumulation in the body's organs.

Uses

The primary use of choline tetrathiomolybdate is in the treatment of Wilson's disease. It may also be used in the treatment of other conditions where copper accumulation is a problem, such as idiopathic pulmonary fibrosis and certain types of cancer.

Side effects

Like all drugs, choline tetrathiomolybdate can cause side effects. These may include nausea, vomiting, diarrhea, and anemia. In rare cases, it can cause more serious side effects such as neutropenia or thrombocytopenia.

History

Choline tetrathiomolybdate was first developed in the 1980s as a potential treatment for Wilson's disease. It has since been studied for use in other conditions and has been found to be effective in reducing copper levels in the body.

See also

• Wilson's disease
• Chelating agent
• Copper

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