Chordin
Chordin is a protein that in humans is encoded by the CHRD gene. Chordin plays a crucial role in embryonic development by regulating the BMP signaling pathway. It is involved in the organization of the body plan and the development of organs and tissues.
Function[edit | edit source]
Chordin is a glycoprotein that inhibits the BMP signaling pathway. It binds to BMPs, preventing them from interacting with their receptors. This inhibition is relieved by the action of the Tolloid family of metalloproteases, which cleave Chordin to release BMPs.
Clinical significance[edit | edit source]
Mutations in the CHRD gene have been associated with a variety of congenital disorders, including scoliosis, craniosynostosis, and heart defects.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
| Chordin Resources | |
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Contributors: Prab R. Tumpati, MD
