Ciclopirox olamine

Ciclopirox olamine
INN
Drug class
Routes of administration	Topical
Pregnancy category
Bioavailability	Negligible
Metabolism	Hepatic
Elimination half-life	1.7 hours
Excretion	Urine
Legal status
CAS Number	29342-05-0
PubChem	2783
DrugBank	DB01188
ChemSpider	2681
KEGG	D07710

Overview

Ciclopirox Olamine is a synthetic antifungal agent used primarily in the treatment of dermatophytosis, onychomycosis, and other fungal infections of the skin and nails. It is available in various formulations, including creams, lotions, and nail lacquers.

Mechanism of Action

Ciclopirox Olamine exerts its antifungal effects by chelating trivalent cations such as Fe³⁺ and Al³⁺, which are essential for the enzymatic activity of fungal cells. This chelation disrupts the synthesis of ergosterol, a critical component of the fungal cell membrane, leading to increased cell permeability and ultimately cell death. Additionally, Ciclopirox has been shown to inhibit mitochondrial electron transport and DNA repair processes in fungal cells.

Pharmacokinetics

Ciclopirox Olamine is applied topically and has negligible systemic absorption. It binds extensively to plasma proteins, with a binding rate of 94-97%. The drug is metabolized in the liver and has an elimination half-life of approximately 1.7 hours. It is primarily excreted in the urine.

Clinical Uses

Ciclopirox Olamine is indicated for the treatment of:

• Tinea pedis (athlete's foot)
• Tinea cruris (jock itch)
• Tinea corporis (ringworm)
• Seborrheic dermatitis
• Onychomycosis (fungal nail infection)

Formulations

Ciclopirox Olamine is available in several formulations, including:

• Creams and lotions for skin infections
• Nail lacquers for onychomycosis
• Shampoos for seborrheic dermatitis

Side Effects

Common side effects of Ciclopirox Olamine include:

• Local irritation
• Erythema
• Pruritus
• Burning sensation

Severe side effects are rare but may include allergic reactions such as rash, itching, and swelling.

Contraindications

Ciclopirox Olamine is contraindicated in individuals with known hypersensitivity to the drug or any of its components. It should be used with caution in pregnant or breastfeeding women, although it is classified as pregnancy category B in the United States.

Interactions

There are no significant drug interactions associated with topical use of Ciclopirox Olamine. However, it is advisable to avoid concurrent use with other topical medications unless directed by a healthcare provider.

See Also

• Antifungal medications
• Dermatophytosis
• Onychomycosis

External Links

• Drugs.com: Ciclopirox Topical
• MedlinePlus: Ciclopirox