Cilnidipine

Article about the calcium channel blocker Cilnidipine

Cilnidipine

Cilnidipine is a calcium channel blocker used in the management of hypertension. It is a dual blocker of L-type and N-type calcium channels, which makes it unique among calcium channel blockers.

Pharmacology

Cilnidipine is a dihydropyridine calcium channel blocker. It works by inhibiting the influx of calcium ions into vascular smooth muscle and cardiac muscle, leading to vasodilation and a reduction in blood pressure. The dual action on L-type and N-type calcium channels provides additional benefits in terms of reducing sympathetic nerve activity.

Mechanism of Action

Cilnidipine blocks L-type calcium channels, which are primarily found in the vascular smooth muscle and the heart. This action leads to vasodilation and decreased peripheral resistance. Additionally, cilnidipine blocks N-type calcium channels, which are located in the sympathetic nervous system. This reduces the release of neurotransmitters such as norepinephrine, further contributing to its antihypertensive effects.

Clinical Use

Cilnidipine is primarily used for the treatment of hypertension. It may be used alone or in combination with other antihypertensive agents. The dual action on both L-type and N-type calcium channels makes it particularly effective in patients with high sympathetic nerve activity.

Side Effects

Common side effects of cilnidipine include dizziness, flushing, headache, and peripheral edema. These are typical of calcium channel blockers due to their vasodilatory effects. Rarely, it may cause bradycardia or hypotension.

Dosage and Administration

Cilnidipine is administered orally, usually once daily. The dosage may vary based on the patient's response and the severity of hypertension. It is important to follow the prescribing physician's instructions and not to discontinue the medication abruptly.

Related pages

• Calcium channel blocker
• Hypertension
• Sympathetic nervous system

• 
  Cilnidipine