Ciprofloxacin/celecoxib

Ciprofloxacin is a fluoroquinolone antibiotic used in the treatment of various bacterial infections. It is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria. Ciprofloxacin functions by inhibiting the DNA gyrase enzyme, which is necessary for bacterial DNA replication.

Celecoxib is a nonsteroidal anti-inflammatory drug (NSAID) used in the treatment of osteoarthritis, rheumatoid arthritis, acute pain, menstrual pain, and to reduce numbers of colon and rectum polyps in patients with familial adenomatous polyposis. It works by reducing hormones that cause inflammation and pain in the body.

Pharmacology

Ciprofloxacin is a second-generation fluoroquinolone that has a broad spectrum of activity. It is bactericidal and works by inhibiting the enzyme DNA gyrase, which is essential for bacterial DNA replication. This leads to DNA fragmentation and ultimately, bacterial cell death.

Celecoxib is a selective COX-2 inhibitor that reduces the production of prostaglandins, chemicals that are responsible for pain and inflammation. By selectively inhibiting COX-2, celecoxib reduces inflammation and pain without causing the stomach upset and ulcers that can be associated with non-selective NSAIDs.

Side Effects

Common side effects of ciprofloxacin include nausea, vomiting, diarrhea, and rash. More serious side effects may include tendon rupture, liver damage, and seizures.

Celecoxib may cause side effects such as stomach pain, constipation, diarrhea, gas, heartburn, nausea, vomiting, and dizziness. More serious side effects may include heart attack, stroke, high blood pressure, heart failure, ulcers, and bleeding.

Interactions

Ciprofloxacin and celecoxib may interact with other medications. It is important to inform your healthcare provider of all medications you are currently taking to avoid any potential drug interactions.

See Also

• Fluoroquinolone
• Nonsteroidal anti-inflammatory drug
• DNA gyrase
• COX-2 inhibitor