Fluoroquinolone

Fluoroquinolone is a type of antibiotic that is used to treat a variety of bacterial infections. This class of drugs includes popular medications such as ciprofloxacin, levofloxacin, and moxifloxacin. Fluoroquinolones work by inhibiting the bacteria's ability to replicate and repair its DNA, thus killing the bacteria and treating the infection.

Mechanism of Action

Fluoroquinolones work by inhibiting the DNA gyrase and topoisomerase IV enzymes. These enzymes are essential for bacterial DNA replication, transcription, repair, and recombination. By inhibiting these enzymes, fluoroquinolones prevent the bacteria from replicating and repairing its DNA, leading to bacterial death.

Uses

Fluoroquinolones are used to treat a variety of bacterial infections, including urinary tract infections, respiratory tract infections, skin infections, gastrointestinal infections, and bone and joint infections. They are also used to treat certain sexually transmitted infections, such as gonorrhea.

Side Effects

Like all medications, fluoroquinolones can cause side effects. Common side effects include nausea, diarrhea, and dizziness. More serious side effects can include tendon rupture, nerve damage, and mental health problems.

Precautions

Fluoroquinolones should be used with caution in people with a history of tendon problems, nerve problems, or mental health problems. They should also be used with caution in people who are taking certain other medications, as they can interact with other drugs.

See Also

• Antibiotic
• Bacterial infection
• DNA gyrase
• Topoisomerase IV

Fluoroquinolone Resources
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