Ciprofloxacin/dexamethasone
An article about the combination drug Ciprofloxacin/dexamethasone
Ciprofloxacin/dexamethasone is a combination medication used primarily in the treatment of ear infections. It combines two active ingredients: ciprofloxacin, an antibiotic, and dexamethasone, a corticosteroid. This combination is commonly marketed under the brand name Ciprodex.
Pharmacology[edit | edit source]
Ciprofloxacin is a fluoroquinolone antibiotic that works by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes critical for bacterial DNA replication. This action results in the death of susceptible bacteria, making it effective against a wide range of Gram-negative bacteria.
Dexamethasone is a potent anti-inflammatory corticosteroid that reduces inflammation by inhibiting multiple inflammatory cytokines and decreasing the permeability of capillaries. This helps to alleviate symptoms such as swelling, redness, and pain associated with infections.
Indications[edit | edit source]
Ciprofloxacin/dexamethasone is indicated for the treatment of acute otitis externa and acute otitis media in patients with tympanostomy tubes. It is particularly useful in cases where inflammation and bacterial infection are both present.
Administration[edit | edit source]
The medication is administered as ear drops. The typical dosage involves instilling a specific number of drops into the affected ear(s) twice daily for a prescribed duration, usually around 7 days. It is important to follow the healthcare provider's instructions regarding dosage and duration to ensure effective treatment.
Side Effects[edit | edit source]
Common side effects of ciprofloxacin/dexamethasone include ear discomfort, itching, and a feeling of fullness in the ear. Rarely, more serious side effects such as allergic reactions or superinfection with non-susceptible organisms may occur.
Precautions[edit | edit source]
Patients should inform their healthcare provider of any known allergies to ciprofloxacin, dexamethasone, or other quinolone antibiotics. It is also important to avoid contaminating the dropper tip with any surfaces, including the ear, to prevent bacterial contamination.
Related pages[edit | edit source]
Ciprofloxacin/dexamethasone
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Contributors: Prab R. Tumpati, MD
