Clentiazem

Clentiazem is a benzothiazepine derivative drug used as an antihypertensive and antianginal agent. It is a calcium channel blocker that is structurally related to diltiazem.

Pharmacology

Clentiazem works by inhibiting the influx of calcium ions into cardiac muscle and smooth muscle cells. This inhibition leads to a decrease in peripheral vascular resistance, which results in a reduction in blood pressure. It also reduces the workload of the heart, which can help to alleviate symptoms of angina pectoris.

Clinical Use

Clentiazem is used in the treatment of hypertension and angina pectoris. It can be used alone or in combination with other antihypertensive drugs. It is also used in the management of arrhythmias.

Side Effects

Like other calcium channel blockers, clentiazem can cause a variety of side effects. These can include dizziness, headache, flushing, and edema. In rare cases, it can cause more serious side effects such as heart failure or arrhythmias.

Contraindications

Clentiazem is contraindicated in patients with known hypersensitivity to the drug or any of its components. It is also contraindicated in patients with sick sinus syndrome, second or third degree heart block, or severe hypotension.

See Also

• Benzothiazepine
• Diltiazem
• Calcium channel blocker
• Hypertension
• Angina pectoris

Clentiazem Resources
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