Clofilium

Clofilium

Clofilium is a potassium channel blocker used in the study of cardiac electrophysiology. It is known to block the delayed rectifier potassium channel, which is crucial in the repolarization phase of the cardiac action potential.

Mechanism of Action

Clofilium works by inhibiting the potassium ion channels in the heart, specifically the delayed rectifier potassium channel. This inhibition prolongs the duration of the action potential, thereby increasing the refractory period. This can lead to a decrease in the heart rate and can be used to treat certain types of arrhythmia.

Pharmacokinetics

The pharmacokinetics of clofilium are not well understood. It is known to be absorbed in the gastrointestinal tract after oral administration, but the extent of absorption and the bioavailability are not known. The drug is metabolized in the liver and excreted in the urine.

Side Effects

The most common side effects of clofilium include nausea, vomiting, and diarrhea. Other side effects can include dizziness, headache, and palpitations. In rare cases, clofilium can cause serious cardiac side effects, including ventricular fibrillation and cardiac arrest.

Contraindications

Clofilium is contraindicated in patients with known hypersensitivity to the drug. It is also contraindicated in patients with severe heart failure, as it can exacerbate the condition.

See Also

• Potassium channel blocker
• Cardiac electrophysiology
• Delayed rectifier potassium channel
• Cardiac action potential