Clomifenoxide

Clomifenoxide is a pharmaceutical drug used in the treatment of infertility in women. It is a non-steroidal fertility drug that stimulates the release of gonadotropins, hormones that are responsible for the development and release of mature ova (egg cells) in the ovaries.

Mechanism of Action

Clomifenoxide works by blocking the action of estrogen on the hypothalamus, a region of the brain that controls the release of hormones from the pituitary gland. This causes the pituitary to release more follicle-stimulating hormone (FSH) and luteinizing hormone (LH), which in turn stimulate the ovaries to produce and release more eggs.

Uses

Clomifenoxide is primarily used to treat infertility in women who have difficulty ovulating due to polycystic ovary syndrome (PCOS) or other disorders. It may also be used in combination with other treatments in assisted reproductive technology (ART) procedures such as in vitro fertilization (IVF).

Side Effects

Like all medications, Clomifenoxide can cause side effects. These may include hot flashes, abdominal discomfort, mood swings, and visual disturbances. In rare cases, it can cause ovarian hyperstimulation syndrome (OHSS), a potentially serious condition characterized by enlarged ovaries and fluid accumulation in the abdomen.

Contraindications

Clomifenoxide should not be used by women who are already pregnant, as it can cause harm to the developing fetus. It is also contraindicated in women with liver disease, uncontrolled thyroid or adrenal gland disorders, an ovarian cyst unrelated to PCOS, or abnormal vaginal bleeding of unknown cause.

See Also

• Infertility
• Polycystic ovary syndrome
• In vitro fertilization
• Ovarian hyperstimulation syndrome