Cloprednol

Cloprednol

Cloprednol is a synthetic glucocorticoid that is used in the treatment of various inflammatory and autoimmune conditions. It is a derivative of prednisolone and has potent anti-inflammatory and immunosuppressive properties.

Pharmacology

Cloprednol works by binding to and activating glucocorticoid receptors, which leads to changes in gene expression. This results in a decrease in the production of pro-inflammatory cytokines and other mediators of inflammation, thereby reducing inflammation and the immune response.

Clinical Use

Cloprednol is used in the treatment of a variety of conditions, including rheumatoid arthritis, asthma, allergic reactions, and certain autoimmune diseases. It is also used in the management of adrenal insufficiency.

Side Effects

Like other glucocorticoids, cloprednol can cause a range of side effects. These can include weight gain, osteoporosis, glaucoma, and Cushing's syndrome. Long-term use can also lead to adrenal suppression.

History

Cloprednol was first synthesized in the 1960s and has been used in clinical practice since the 1970s. It is available in several countries, including Japan, South Korea, and Italy.

See Also

• Glucocorticoid
• Prednisolone
• Inflammation
• Autoimmune disease