Clue cell

Clue Cell

A microscopic image of clue cells

Clue cells are a diagnostic feature used in the field of gynecology to identify a condition called bacterial vaginosis (BV). BV is a common vaginal infection caused by an imbalance in the normal bacterial flora of the vagina. Clue cells are epithelial cells that are covered with bacteria, making them appear "clue-like" under a microscope.

Identification

To identify clue cells, a sample of vaginal discharge is collected and examined under a microscope. Clue cells can be easily identified due to their distinct appearance. They are typically larger than normal vaginal epithelial cells and have a stippled or granular appearance. The presence of bacteria adhering to the surface of these cells is a key characteristic used to diagnose BV.

Significance

The presence of clue cells in vaginal discharge is a strong indicator of bacterial vaginosis. BV is characterized by an overgrowth of certain bacteria, such as Gardnerella vaginalis, which adhere to the vaginal epithelial cells. The bacteria produce enzymes that break down the normal protective barrier of the vagina, leading to an increase in vaginal discharge and a characteristic fishy odor.

Treatment

The treatment of bacterial vaginosis typically involves the use of antibiotics, such as metronidazole or clindamycin. These medications help to restore the balance of bacteria in the vagina and alleviate the symptoms associated with BV. It is important to complete the full course of antibiotics as prescribed by a healthcare professional to ensure effective treatment.

Prevention

To prevent the recurrence of bacterial vaginosis, it is recommended to maintain good vaginal hygiene. This includes avoiding the use of harsh soaps or douches, as they can disrupt the natural balance of bacteria in the vagina. Wearing breathable cotton underwear and avoiding tight-fitting clothing can also help to prevent the growth of harmful bacteria.

See Also

• Bacterial vaginosis
• Gardnerella vaginalis
• Vaginal hygiene