Complexin

PDB 1kil EBI

Complexin

Complexin is a protein that plays a crucial role in regulating neurotransmitter release in the brain. It is primarily found at the synapses of neurons, where it interacts with other proteins involved in the process of synaptic vesicle fusion and neurotransmitter release.

Function

Complexin functions as a regulator of synaptic vesicle exocytosis by modulating the activity of the SNARE complex, a group of proteins responsible for membrane fusion during neurotransmitter release. By binding to the SNARE complex, Complexin helps to fine-tune the timing and efficiency of neurotransmitter release, ensuring proper communication between neurons.

Structure

The structure of Complexin consists of several domains that allow it to interact with the SNARE complex and other regulatory proteins. These domains enable Complexin to bind to specific regions of the SNARE complex, influencing its function and ultimately controlling neurotransmitter release.

Regulation

The activity of Complexin is tightly regulated to ensure precise control of neurotransmitter release. Various signaling pathways and protein interactions can modulate the function of Complexin, allowing for dynamic adjustments in synaptic transmission based on the demands of the nervous system.

Clinical Implications

Dysregulation of Complexin has been implicated in various neurological disorders, including epilepsy and schizophrenia. Mutations in the gene encoding Complexin or alterations in its expression levels can disrupt synaptic function and contribute to the pathophysiology of these conditions.

Conclusion

In summary, Complexin is a critical player in the intricate process of neurotransmitter release at synapses. Its regulatory role in modulating synaptic vesicle fusion highlights its importance in maintaining proper neuronal communication and underscores its potential as a target for therapeutic interventions in neurological disorders.