Concentrative nucleoside transporters

Concentrative nucleoside transporters (CNTs) are a type of protein that facilitate the transport of nucleosides across the cell membrane. These proteins are integral to the function of cells, as nucleosides are essential components of nucleic acids, which are necessary for the storage and transmission of genetic information.

Function

CNTs are responsible for the active transport of nucleosides from the extracellular space into the cell. This process is essential for the synthesis of nucleic acids and the regulation of many cellular processes. In addition to nucleosides, CNTs can also transport nucleoside-derived drugs, making them important in the field of pharmacology.

Structure

CNTs are transmembrane proteins, meaning they span the entire cell membrane. They have a complex structure that allows them to bind to nucleosides and transport them across the cell membrane. The exact structure of CNTs can vary between different species and cell types.

Types

There are three known types of CNTs: CNT1, CNT2, and CNT3. Each type has a different affinity for various nucleosides and nucleoside-derived drugs. This diversity allows cells to regulate the uptake of different nucleosides and drugs.

Clinical significance

CNTs have been implicated in a number of diseases, including cancer, cardiovascular disease, and infectious disease. They are also important targets for a number of drugs, including chemotherapy agents and antiviral drugs.

See also

• Nucleoside
• Cell membrane
• Protein
• Nucleic acid

References

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