ConoServer

ConoServer is a specialized database that provides comprehensive information on conopeptides, which are small, naturally occurring peptides found in the venom of cone snails (genus Conus). These peptides have significant potential in pharmacology and neuroscience due to their ability to target specific ion channels and receptors in the nervous system.

Overview

ConoServer was developed to facilitate the study and application of conopeptides by providing a centralized repository of data. The database includes detailed information on the sequences, structures, and biological activities of conopeptides. Researchers can access data on the taxonomy of cone snails, the genetic sequences of conopeptides, and their pharmacological properties.

Features

ConoServer offers several key features:

• **Sequence Data**: Detailed amino acid sequences of conopeptides.
• **Structural Information**: Three-dimensional structures of conopeptides, often determined through X-ray crystallography or NMR spectroscopy.
• **Biological Activity**: Information on the biological targets of conopeptides, including specific ion channels and receptors.
• **Taxonomic Data**: Classification and taxonomy of cone snail species that produce the peptides.

Applications

Conopeptides have a wide range of applications in biomedical research and drug development. They are particularly valuable in the study of pain management, neurological disorders, and cardiovascular diseases. Some conopeptides have been developed into therapeutic drugs, such as Ziconotide, which is used to treat severe chronic pain.

Access and Usage

Researchers can access ConoServer through its web interface, which allows for the browsing and searching of the database. The interface provides tools for sequence alignment, structural visualization, and the prediction of biological activity. ConoServer is an essential resource for scientists working in the fields of toxinology, pharmacology, and neuroscience.

See Also

• Conopeptide
• Cone snail
• Ion channel
• Neuroscience
• Pharmacology