Contezolid acefosamil

Contezolid acefosamil is an antibiotic drug that is used in the treatment of bacterial infections. It is a prodrug of contezolid and is part of the oxazolidinone class of antibiotics.

Pharmacology[edit | edit source]

Contezolid acefosamil is a prodrug, which means it is an inactive compound that is metabolized in the body to produce an active drug. In this case, the active drug is contezolid. The conversion of contezolid acefosamil to contezolid occurs in the liver through the process of hydrolysis.

The pharmacokinetics of contezolid acefosamil are characterized by rapid absorption and conversion to contezolid. The drug has a half-life of approximately 12 hours, allowing for twice-daily dosing.

Clinical Use[edit | edit source]

Contezolid acefosamil is used in the treatment of Gram-positive bacterial infections, including those caused by methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE). It is also effective against tuberculosis bacteria.

Side Effects[edit | edit source]

As with all antibiotics, contezolid acefosamil can cause side effects. The most common side effects include nausea, vomiting, and diarrhea. Less common side effects can include headache, dizziness, and rash.

Development and Approval[edit | edit source]

Contezolid acefosamil was developed by Microbiotix, a biopharmaceutical company based in the United States. It was approved for use in China in 2020 by the National Medical Products Administration (NMPA).

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