Copine 3
Copine 3 is a protein that in humans is encoded by the CPNE3 gene. It is a member of the copine family, a group of proteins characterized by the presence of two C2 domains and one von Willebrand factor A (VWA) domain.
Function[edit | edit source]
The copine family members are known to be calcium-dependent, phospholipid-binding proteins. Copine 3, like other members of the copine family, may have a role in membrane trafficking. It has been suggested that copine 3 may be involved in the regulation of epidermal growth factor receptor (EGFR) trafficking and EGFR signaling.
Clinical significance[edit | edit source]
Alterations in the CPNE3 gene have been associated with various diseases. For instance, a study found that CPNE3 was significantly upregulated in ovarian cancer tissues, suggesting that it may play a role in the progression of this disease.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
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