Corvalol
Corvalol is a barbiturate-based heart medication and a mild tranquilizer, popular in Eastern Europe and the former Soviet Union. It is a transparent liquid with a characteristic strong aroma. In appearance, it is a crystal-clear liquid that exudes a potent, characteristic aroma.
Chemical Composition of Corvalol[edit | edit source]
Breaking down the contents of this unique medication, a standard dose of Corvalol (1 ml) boasts the following active components:
- Phenobarbital – 16 mg: A barbiturate, often used for its sedative effects.
- Bromisovalum – 20 mg: A derivative combining bromine and valeric acid. Alternatively, this can be found as Ethylbromisovalerinate (ethyl ester of α-Bromoisovaleric acid) – 20 mg.
- Peppermint oil – 1.5 mg: Often used for its aromatic properties and potential therapeutic effects.
- Hop oil – 0.2 mg: Occasionally found in the composition, known for its calming properties.
Beyond these active ingredients, Corvalol incorporates certain inactive elements to ensure stability and solubility:
Sodium hydroxide: Employed to convert the less soluble phenobarbital into its more soluble counterpart, phenobarbital sodium. Ethanol and water: Act as solutes, enhancing the overall solubility of the ingredients.
Corvalol vs. Valocordin: A Comparative Insight[edit | edit source]
Here's where our tale of two medicines begins:
Corvalol and Valocordin are like two peas in a pod, with their compositions and effects mirroring each other closely. The point of divergence? Their birthplaces.
- Corvalol: This medication finds its origin in Eastern Europe.
- Valocordin: Manufactured in the heart of Germany, Valocordin carries the badge of being a product of German pharmaceutical craftsmanship. The term "Valocordin" is not merely a name but a registered trademark held dearly by the German pharmaceutical titan, Krewel Meuselbach GmbH.
Sedatives and Hypnotics[edit source]
- Herbals
- Chamomile (Matricaria recutita)
- Hops (Humulus lupulus)
- Lavender (Lavandula angustifolia)
- Passionflower (Passiflora incarnata)
- Valerian (Valeriana officinalis)
- Melatonin and its Analogues
Miscellaneous Agents
- Buspirone
- Chloral hydrate
- Doxepin
- Meprobamate
- Sodium Oxybate (Narcolepsy Agent)
- Suvorexant
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Contributors: Prab R. Tumpati, MD
