Corvalol

Corvalol is a barbiturate-based heart medication and a mild tranquilizer, popular in Eastern Europe and the former Soviet Union. It is a transparent liquid with a characteristic strong aroma. In appearance, it is a crystal-clear liquid that exudes a potent, characteristic aroma.

Корвалол-Фармак

Chemical Composition of Corvalol

Breaking down the contents of this unique medication, a standard dose of Corvalol (1 ml) boasts the following active components:

• Phenobarbital – 16 mg: A barbiturate, often used for its sedative effects.
• Bromisovalum – 20 mg: A derivative combining bromine and valeric acid. Alternatively, this can be found as Ethylbromisovalerinate (ethyl ester of α-Bromoisovaleric acid) – 20 mg.
• Peppermint oil – 1.5 mg: Often used for its aromatic properties and potential therapeutic effects.
• Hop oil – 0.2 mg: Occasionally found in the composition, known for its calming properties.

Beyond these active ingredients, Corvalol incorporates certain inactive elements to ensure stability and solubility:

Sodium hydroxide: Employed to convert the less soluble phenobarbital into its more soluble counterpart, phenobarbital sodium. Ethanol and water: Act as solutes, enhancing the overall solubility of the ingredients.

Corvalol vs. Valocordin: A Comparative Insight

Here's where our tale of two medicines begins:

Corvalol and Valocordin are like two peas in a pod, with their compositions and effects mirroring each other closely. The point of divergence? Their birthplaces.

• Corvalol: This medication finds its origin in Eastern Europe.
• Valocordin: Manufactured in the heart of Germany, Valocordin carries the badge of being a product of German pharmaceutical craftsmanship. The term "Valocordin" is not merely a name but a registered trademark held dearly by the German pharmaceutical titan, Krewel Meuselbach GmbH.

Sedatives and Hypnotics

• Antihistamines
• Diphenhydramine
• Doxylamine
• Hydroxyzine

• Barbiturates
  • Amobarbital
  • Butabarbital
  • Phenobarbital
  • Secobarbital

• Benzodiazepines
  • Diazepam
  • Estazolam
  • Flurazepam
  • Quazepam
  • Temazepam
  • Triazolam

• Benzodiazepine Receptor Agonists
  • Eszopiclone
  • Zaleplon
  • Zolpidem

• Herbals
  • Chamomile (Matricaria recutita)
  • Hops (Humulus lupulus)
  • Lavender (Lavandula angustifolia)
  • Passionflower (Passiflora incarnata)
  • Valerian (Valeriana officinalis)

• Melatonin and its Analogues
  • Melatonin
  • Ramelteon
  • Tasimelteon

Miscellaneous Agents

• • Buspirone
  • Chloral hydrate
  • Doxepin
  • Meprobamate
  • Sodium Oxybate (Narcolepsy Agent)
  • Suvorexant

 

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