Crowe sign

Crowe Sign is a clinical sign associated with Neurofibromatosis type 1 (NF1), a genetic disorder characterized by the development of multiple benign tumors of nerves and skin (neurofibromas) and areas of abnormal skin color (pigmentation). The Crowe sign specifically refers to the presence of axillary freckling in individuals with NF1. These freckles are also known as "Crowe's spots" and are considered one of the diagnostic criteria for NF1.

Clinical Presentation[edit | edit source]

Crowe sign is characterized by the presence of multiple, smooth, brownish spots located in the armpits (axillae). These spots are similar in appearance to freckles but are found in areas not typically exposed to the sun. The presence of six or more café-au-lait spots larger than 5mm in prepubertal individuals or larger than 15mm in postpubertal individuals, along with two or more neurofibromas of any type or one plexiform neurofibroma, are part of the diagnostic criteria for NF1, with Crowe sign being an additional supportive feature.

Diagnosis[edit | edit source]

The diagnosis of NF1 is primarily clinical, based on specific criteria known as the National Institutes of Health (NIH) diagnostic criteria for Neurofibromatosis type 1. Crowe sign can be an important component of this diagnosis. A thorough physical examination, family history, and, in some cases, genetic testing for mutations in the NF1 gene are also part of the diagnostic process.

Significance[edit | edit source]

The significance of Crowe sign lies in its utility as a diagnostic criterion for NF1. Early diagnosis of NF1 is crucial for the management of the condition, as individuals with NF1 are at increased risk for various complications, including learning disabilities, skeletal abnormalities, and an increased risk of certain types of cancer. Recognizing Crowe sign can prompt further investigation and early intervention, potentially improving the quality of life for those affected.

Management[edit | edit source]

Management of NF1 is multidisciplinary and may involve dermatologists, neurologists, geneticists, and other specialists, depending on the manifestations of the disease. While there is no cure for NF1, treatment focuses on monitoring and managing symptoms and complications as they arise. This may include surgical removal of problematic neurofibromas, management of learning disabilities, and regular monitoring for the development of malignancies.