Cvc
Cvc - an orally bioavailable, dual inhibitor of human c-c chemokine receptor types 2 (ccr2; cd192) and 5 (ccr5; cd195), with potential immunomodulating, anti-inflammatory and antiviral activities. Upon oral administration, cenicriviroc specifically binds to and prevents the activation of both ccr2 and ccr5. This inhibits the activation of ccr2/ccr5-mediated signal transduction pathways and may inhibit inflammatory processes. The g-protein coupled chemokine receptors ccr2 and ccr5 are expressed on the surface of monocytes and macrophages and stimulate their migration and infiltration; they play key roles in inflammation and autoimmune diseases. In addition, cenicriviroc inhibits human immunodeficiency virus (hiv)-1 entry via ccr5 coreceptor interaction.
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