Cycloclavine

Cycloclavine is a type of ergoline alkaloid. It is a naturally occurring compound found in various species of fungi, including those in the Claviceps genus.

Chemical Structure

Cycloclavine has a complex chemical structure, which includes a tricyclic system. This structure is composed of a tetracyclic ergoline system, which is fused with a pyrrolidine ring. The ergoline system is a common feature of many alkaloids, and is responsible for their biological activity.

Biological Activity

The biological activity of cycloclavine is not fully understood. However, it is known to have psychoactive properties, and has been found to inhibit the enzyme adenylyl cyclase. This enzyme is involved in the regulation of many biological processes, including cell growth and differentiation, and the response to hormones and neurotransmitters.

Toxicity

Cycloclavine is toxic, and ingestion can lead to a variety of symptoms. These include hallucinations, nausea, vomiting, and in severe cases, gangrene. The toxicity of cycloclavine is due to its ability to constrict blood vessels, which can lead to a lack of blood flow to the extremities.

See Also

• Ergot alkaloids
• Ergotism
• Ergotamine

References

Cycloclavine Resources
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