Cyclopyrrolone

Cyclopyrrolone is a class of psychoactive drugs that are primarily used as sedatives and hypnotics. These drugs are chemically related to the pyrrolidinone family. The most well-known cyclopyrrolone is zopiclone, which is used for the treatment of insomnia.

History

Cyclopyrrolones were first synthesized in the late 20th century as a new class of psychoactive drugs. They were developed as an alternative to benzodiazepines, which were commonly used for the treatment of insomnia and anxiety but had significant side effects and potential for addiction.

Pharmacology

Cyclopyrrolones act on the GABA receptors in the brain, specifically the GABA-A receptor. They enhance the effect of GABA, a neurotransmitter that inhibits the activity of the brain and nervous system. This results in sedative, hypnotic, anxiolytic, and muscle relaxant effects.

Medical uses

Cyclopyrrolones are primarily used for the treatment of insomnia. They help to reduce the time it takes to fall asleep and increase the length of sleep. They are also used for the treatment of certain forms of anxiety, especially when it is accompanied by sleep disturbances.

Side effects

Like all psychoactive drugs, cyclopyrrolones have potential side effects. These can include drowsiness, dizziness, and impaired coordination. There is also a risk of dependency and withdrawal symptoms if the drug is used for a long period of time or at high doses.

See also

• Benzodiazepine
• Nonbenzodiazepine
• Zopiclone
• Eszopiclone
• Pyrrolidinone