Cytoglobin
Cytoglobin is a protein that in humans is encoded by the CYGB gene. It is a member of the globin family and is expressed in fibroblasts, chondrocytes, and neurons.
Function[edit | edit source]
Cytoglobin is a hexacoordinate globin, meaning it binds to heme with both a histidine residue and a distal amino acid. This allows it to perform a variety of functions, including oxygen transport, detoxification, and protection against oxidative stress.
Structure[edit | edit source]
The structure of cytoglobin is similar to that of other globins, with eight alpha helices and a heme group in the center. However, it also has two additional helices at the N-terminus, which are thought to be involved in the hexacoordination of the heme group.
Clinical significance[edit | edit source]
Alterations in the expression of cytoglobin have been associated with a variety of diseases, including cancer, fibrosis, and neurodegenerative diseases.
See also[edit | edit source]
References[edit | edit source]
External links[edit | edit source]
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Contributors: Prab R. Tumpati, MD
