Cytoskeleton associated protein 2 like

Cytoskeleton-associated protein 2-like (CKAP2L) is a protein that in humans is encoded by the CKAP2L gene. This protein is involved in the organization of the cytoskeleton, which is crucial for cell division and cellular structure.

Function

CKAP2L plays a significant role in the stabilization of microtubules, which are components of the cytoskeleton. Microtubules are essential for mitosis, where they form the mitotic spindle that segregates chromosomes into daughter cells. CKAP2L is also implicated in the regulation of cell cycle progression.

Clinical Significance

Mutations in the CKAP2L gene have been associated with Filippi syndrome, a rare genetic disorder characterized by microcephaly, syndactyly, and intellectual disability. Research suggests that CKAP2L mutations disrupt normal cell division, leading to the developmental abnormalities observed in this syndrome.

Interactions

CKAP2L interacts with several other proteins involved in cell division, including tubulin and centrosomal proteins. These interactions are critical for the proper assembly and function of the mitotic spindle.

Research

Ongoing research is focused on understanding the precise molecular mechanisms by which CKAP2L regulates microtubule dynamics and its role in cancer cell proliferation. Studies are also exploring potential therapeutic targets for conditions associated with CKAP2L dysfunction.

See Also

• Cytoskeleton
• Microtubule
• Cell cycle
• Filippi syndrome

External Links

• [CKAP2L Gene - GeneCards](https://www.genecards.org/cgi-bin/carddisp.pl?gene=CKAP2L)
• [CKAP2L Protein - UniProt](https://www.uniprot.org/uniprot/Q8IWY9)

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