Döhle

Döhle bodies are small, round or rod-shaped, basophilic inclusions that are found in the cytoplasm of neutrophils. They are named after the German pathologist Karl Döhle, who first described them in 1901. Döhle bodies are most commonly associated with infections, burns, and other conditions that cause an increase in the number of neutrophils in the blood.

Appearance and Composition

Döhle bodies appear as light blue or grayish-blue inclusions in the cytoplasm of neutrophils when stained with Wright's stain. They are composed of rough endoplasmic reticulum and free ribosomes, which are involved in protein synthesis.

Clinical Significance

Döhle bodies are often seen in conditions that cause an increase in the number of neutrophils, such as bacterial infections, burns, and trauma. They are also seen in certain genetic disorders, such as May-Hegglin anomaly and Sebastian syndrome, which are characterized by the presence of Döhle bodies and other abnormalities in the blood cells.

Diagnosis

The presence of Döhle bodies can be detected through a blood smear examination. In this test, a sample of the patient's blood is spread on a glass slide, stained, and examined under a microscope. The Döhle bodies appear as small, blue inclusions in the cytoplasm of the neutrophils.

Treatment

The treatment for conditions associated with Döhle bodies depends on the underlying cause. For example, bacterial infections are typically treated with antibiotics, while burns and trauma may require surgical intervention.

See Also

• Neutrophil
• Blood smear
• May-Hegglin anomaly
• Sebastian syndrome

Döhle Resources
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