D-α-Aminoadipate

D-α-Aminoadipate‏‎ (also known as D-AAA or D-alpha-aminoadipate) is a biochemical compound that plays a significant role in the metabolism of certain organisms. It is a derivative of the amino acid lysine, and is involved in the biosynthesis of lysine and several other amino acids.

Structure and Properties

D-α-Aminoadipate‏‎ is a chiral molecule, meaning it has a non-superimposable mirror image. It is the D-enantiomer of α-aminoadipate, the other being L-α-aminoadipate. The compound has a carboxyl group (-COOH) and an amino group (-NH2), making it an α-amino acid. However, unlike most α-amino acids, it is not used in the biosynthesis of proteins.

Biological Role

In certain bacteria, fungi, and algae, D-α-Aminoadipate‏‎ is an intermediate in the biosynthesis of the essential amino acid lysine. This pathway, known as the α-aminoadipate pathway, is not found in animals or plants. In the yeast Saccharomyces cerevisiae, D-α-Aminoadipate is also used in the synthesis of penicillin and other β-lactam antibiotics.

In humans and other mammals, D-α-Aminoadipate has been found to act as an excitatory amino acid neurotransmitter. It is also a potential biomarker for certain neurological and metabolic disorders.

Clinical Significance

Elevated levels of D-α-Aminoadipate in the body can be indicative of certain health conditions. For instance, it has been associated with glutaric aciduria, a rare genetic metabolic disorder. It is also being studied for its potential role in neurodegenerative diseases such as Alzheimer's disease and Huntington's disease.

See Also

• Lysine
• Amino acid metabolism
• Neurotransmitter
• Metabolic disorder

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