DAN

DAN (Differential Adhesion Hypothesis) is a scientific theory that explains the organization of cells in the development of embryonic tissues and organs. It was proposed by Malcolm Steinberg in 1963.

Overview

The Differential Adhesion Hypothesis (DAN) suggests that the differences in the adhesive properties of cells lead to the sorting of dissimilar cells and the spatial organization of cells in a tissue. This is similar to the way in which oil and water separate due to differences in their adhesive properties. The hypothesis has been supported by numerous experimental studies and has been used to explain the organization of cells in a variety of tissues and organs.

Principles

The DAN is based on two main principles. The first is that cells have inherent differences in their adhesive properties. This is due to the presence of cell adhesion molecules (CAMs) on the surface of cells. The second principle is that cells will sort themselves based on these differences in adhesion. Cells with similar adhesive properties will stick together, while cells with different adhesive properties will separate.

Applications

The DAN has been used to explain the organization of cells in a variety of tissues and organs. For example, it has been used to explain the sorting of cells in the developing embryo, the organization of cells in the epidermis, and the formation of tumors.

Criticisms

While the DAN has been widely accepted, it has also been criticized. Some scientists argue that the hypothesis is too simplistic and does not take into account other factors that may influence cell sorting and organization. These factors include the mechanical properties of cells, the presence of chemical signals, and the influence of the extracellular matrix.

See also

• Cell adhesion
• Cell sorting
• Embryogenesis
• Tumor formation

References

DAN Resources
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