DBL-583
DBL-583 is a chemical compound that is used in the field of medicine and pharmacology. It is a potent and selective inhibitor of the enzyme cytochrome P450 3A4 (CYP3A4), which is involved in the metabolism of many drugs and other xenobiotics.
Chemistry[edit | edit source]
DBL-583 is a synthetic compound with a molecular formula of C22H19ClN2O3. It is a white to off-white crystalline powder that is soluble in DMSO and ethanol, but insoluble in water.
Pharmacology[edit | edit source]
DBL-583 inhibits the enzyme CYP3A4, which is involved in the metabolism of many drugs and other xenobiotics. By inhibiting this enzyme, DBL-583 can increase the bioavailability of drugs that are metabolized by CYP3A4, potentially enhancing their therapeutic effects or increasing their toxicity.
Clinical significance[edit | edit source]
The inhibition of CYP3A4 by DBL-583 has potential implications for drug-drug interactions. Many drugs are metabolized by CYP3A4, and inhibition of this enzyme can increase the plasma concentrations of these drugs, potentially leading to increased therapeutic effects or toxicity. Therefore, the use of DBL-583 in combination with other drugs that are metabolized by CYP3A4 should be done with caution.
See also[edit | edit source]
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