DBL-583

DBL-583 is a chemical compound that is used in the field of medicine and pharmacology. It is a potent and selective inhibitor of the enzyme cytochrome P450 3A4 (CYP3A4), which is involved in the metabolism of many drugs and other xenobiotics.

Chemistry

DBL-583 is a synthetic compound with a molecular formula of C₂₂H₁₉ClN₂O₃. It is a white to off-white crystalline powder that is soluble in DMSO and ethanol, but insoluble in water.

Pharmacology

DBL-583 inhibits the enzyme CYP3A4, which is involved in the metabolism of many drugs and other xenobiotics. By inhibiting this enzyme, DBL-583 can increase the bioavailability of drugs that are metabolized by CYP3A4, potentially enhancing their therapeutic effects or increasing their toxicity.

Clinical significance

The inhibition of CYP3A4 by DBL-583 has potential implications for drug-drug interactions. Many drugs are metabolized by CYP3A4, and inhibition of this enzyme can increase the plasma concentrations of these drugs, potentially leading to increased therapeutic effects or toxicity. Therefore, the use of DBL-583 in combination with other drugs that are metabolized by CYP3A4 should be done with caution.

See also

• Cytochrome P450
• Drug metabolism
• Pharmacokinetics

DBL-583 Resources
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