DDX53

DDX53

DDX53, also known as DEAD-box helicase 53, is a protein that in humans is encoded by the DDX53 gene. This protein belongs to the DEAD-box family of RNA helicases, which are characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD).

Function

DDX53 is a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly.

Clinical significance

DDX53 has been identified as a potential biomarker for cancer, particularly in the diagnosis and prognosis of colorectal cancer. Studies have shown that the overexpression of DDX53 is associated with poor prognosis in colorectal cancer patients.

See also

• DEAD box
• RNA helicase
• Gene
• Protein
• Cancer

External links

• Gene
• UniProt