DEFB104A

Ideogram human chromosome 8

== DEFB104A ==

DEFB104A is a gene that encodes for a protein known as defensin beta 104A. Defensins are a class of antimicrobial peptides that play a crucial role in the innate immune response of various organisms. Defensin beta 104A is specifically involved in the defense against microbial pathogens by disrupting their cell membranes.

Structure and Function

Defensin beta 104A is a small protein consisting of approximately 40-50 amino acids. It adopts a characteristic three-dimensional structure that allows it to interact with and disrupt the lipid membranes of bacteria, fungi, and other pathogens. This disruption leads to the death of the invading microorganisms, thereby helping to protect the host organism from infection.

Role in Immunity

The expression of DEFB104A is primarily found in epithelial cells lining various mucosal surfaces, such as the respiratory tract, gastrointestinal tract, and skin. By secreting defensin beta 104A, these cells contribute to the local defense against pathogens that may come into contact with these surfaces. Additionally, defensin beta 104A has been shown to have immunomodulatory effects, influencing the activity of immune cells involved in the inflammatory response.

Clinical Implications

Mutations or dysregulation of DEFB104A expression have been associated with certain infectious diseases and inflammatory conditions. Understanding the role of defensin beta 104A in the immune response may provide insights into the development of novel therapeutic strategies for combating infections and inflammatory disorders.

See Also

• Defensin
• Antimicrobial Peptides
• Innate Immune Response