DHEA-S

DHEA-S or Dehydroepiandrosterone sulfate is a steroid hormone produced by the adrenal gland. It is the most abundant circulating steroid in the human body and plays a crucial role in a variety of biological functions.

Production and Function[edit | edit source]

DHEA-S is synthesized from cholesterol in the adrenal glands and is then converted into androgens, estrogens, and other hormones. These sex hormones are responsible for the development and maintenance of secondary sexual characteristics in both men and women.

In addition to its role in the production of sex hormones, DHEA-S also has a number of other functions. It is involved in the regulation of immune function, brain function, bone metabolism, mood, energy levels, and the ability to handle stress.

Clinical Significance[edit | edit source]

Abnormal levels of DHEA-S can be indicative of various medical conditions. High levels of DHEA-S can be associated with polycystic ovary syndrome (PCOS), Cushing's syndrome, and adrenal tumors. On the other hand, low levels of DHEA-S can be associated with Addison's disease, hypopituitarism, and adrenal insufficiency.

DHEA-S levels can be measured in the blood to help diagnose these conditions and to monitor treatment. However, it is important to note that DHEA-S levels naturally decrease with age, and therefore, age-specific reference ranges should be used when interpreting DHEA-S levels.