Dehydroepiandrosterone sulfate

Dehydroepiandrosterone sulfate (DHEAS) is a steroid hormone produced by the adrenal gland. It is the most abundant circulating steroid in the human body and can be converted into other hormones, such as estrogen and testosterone. DHEAS plays a role in a variety of bodily functions, including immune system response, brain function, and bone density.

Production and Function

DHEAS is produced in the adrenal cortex, the outer layer of the adrenal gland. The production of DHEAS is controlled by the adrenocorticotropic hormone (ACTH), which is released by the pituitary gland.

The primary function of DHEAS is to serve as a precursor for the production of sex hormones. It can be converted into androgens and estrogens, the male and female sex hormones, respectively.

In addition to its role in hormone production, DHEAS also has other functions in the body. It has been shown to have an effect on the immune system, and it may also play a role in brain function and bone density.

Measurement of DHEAS Levels

The levels of DHEAS in the body can be measured with a blood test. This test can be used to diagnose conditions related to the adrenal gland, such as Addison's disease or Cushing's syndrome. It can also be used to determine the cause of hirsutism (excessive hair growth) or virilization (development of male characteristics) in women.

Health Implications

Abnormal levels of DHEAS can indicate a variety of health conditions. High levels of DHEAS can be a sign of an adrenal tumor or polycystic ovary syndrome (PCOS). Low levels of DHEAS can be a sign of adrenal insufficiency or hypopituitarism.

See Also

• Adrenal gland
• Steroid hormone
• Estrogen
• Testosterone
• Adrenocorticotropic hormone
• Pituitary gland
• Androgens
• Estrogens
• Addison's disease
• Cushing's syndrome
• Hirsutism
• Virilization
• Adrenal tumor
• Polycystic ovary syndrome
• Adrenal insufficiency
• Hypopituitarism

• 
  Steroidogenesis pathway
• 
  Dehydroepiandrosterone sulfate levels throughout life in human males and females