DIDO1

DIDO1 (Death Inducer-Obliterator 1) is a gene that encodes a protein in humans. This protein is involved in cell death and cell survival, playing a crucial role in cellular differentiation and apoptosis.

Function

The DIDO1 gene is known to encode three different isoforms of a protein, each with distinct biological functions. The longest isoform (isoform 1) is necessary for pluripotency of embryonic stem cells. The shorter isoforms (isoforms 2 and 3), on the other hand, are involved in the induction of apoptosis.

Clinical Significance

Alterations in the DIDO1 gene have been associated with several types of cancer, including leukemia and breast cancer. Studies have shown that overexpression of the DIDO1 gene can lead to increased cell survival and resistance to apoptosis, which can contribute to the development and progression of cancer.

Research

Research into the DIDO1 gene and its associated protein is ongoing, with scientists seeking to better understand its role in cell survival and death, as well as its potential as a target for cancer therapy.

See Also

• Gene
• Protein
• Apoptosis
• Cancer