DNAI2

DNAI2 (Dynein Axonemal Intermediate Chain 2) is a protein that in humans is encoded by the DNAI2 gene. This protein is part of the dynein complex in cilia and flagella.

Function

The DNAI2 protein is an intermediate chain of the dynein complex, which is a large multi-subunit complex found in both cilia and flagella. Dynein is responsible for the bending movements of cilia and flagella, which are hair-like structures found on the surface of many types of cells. These structures are involved in a variety of functions, including cell movement, sensory perception, and the movement of fluids over cell surfaces.

Clinical significance

Mutations in the DNAI2 gene have been associated with primary ciliary dyskinesia (PCD), a rare genetic disorder characterized by chronic respiratory tract infections, abnormally positioned internal organs, and infertility. PCD is caused by abnormal ciliary and flagellar structure and function, leading to impaired mucociliary clearance.

See also

• Dynein
• Primary ciliary dyskinesia
• Cilia
• Flagella

External links

• NCBI Gene
• Genetics Home Reference