DNA damage-inducible transcript 3

DNA damage-inducible transcript 3 (also known as DDIT3, CHOP, GADD153) is a gene that encodes a transcription factor involved in cellular stress responses. It is a member of the C/EBP family of transcription factors and is predominantly expressed in response to cellular stress, particularly endoplasmic reticulum stress and DNA damage.

Function

The DDIT3 protein is a transcription factor that regulates gene expression in response to cellular stress. It is involved in a variety of cellular processes, including apoptosis, cell cycle regulation, and inflammation. In response to stress, DDIT3 can induce cell cycle arrest and apoptosis, thereby preventing the propagation of damaged cells.

Role in Disease

Alterations in the expression or function of DDIT3 have been implicated in a variety of diseases, including cancer, neurodegenerative diseases, and metabolic disorders. In cancer, overexpression of DDIT3 has been associated with increased tumor growth and resistance to chemotherapy. In neurodegenerative diseases, DDIT3 has been implicated in the induction of neuronal cell death. In metabolic disorders, DDIT3 has been linked to insulin resistance and type 2 diabetes.

Research

Research into the role of DDIT3 in disease has led to the development of potential therapeutic strategies. For example, inhibitors of DDIT3 have been proposed as potential treatments for cancer and neurodegenerative diseases. Conversely, activators of DDIT3 have been proposed as potential treatments for metabolic disorders.

See Also

• C/EBP
• Apoptosis
• Cell cycle
• Endoplasmic reticulum stress
• DNA damage