DSG3

From WikiMD's Wellness Encyclopedia

DSG3 (Desmoglein 3) is a protein that in humans is encoded by the DSG3 gene. It is a member of the desmoglein family and cadherin cell adhesion molecule superfamily of proteins. DSG3 is found in the desmosome structures of epithelial cells, particularly those of the skin and mucous membranes.

Function[edit | edit source]

DSG3 plays a crucial role in the formation and maintenance of cell adhesion structures called desmosomes. These structures are found in epithelial cells, which line the surfaces and cavities of the body. Desmosomes provide strength to tissues by ensuring that cells are bound together. They are particularly important in areas of the body that experience a lot of friction and wear and tear, such as the skin and the lining of the mouth.

Clinical significance[edit | edit source]

Mutations in the DSG3 gene, as well as the presence of autoantibodies against DSG3, are associated with the autoimmune blistering disease pemphigus vulgaris. This condition is characterized by the formation of blisters in the skin and mucous membranes. In pemphigus vulgaris, the immune system mistakenly attacks the desmosomes, leading to a loss of cell adhesion and the formation of blisters.

See also[edit | edit source]

References[edit | edit source]


External links[edit | edit source]

DSG3 Resources
Wikipedia
WikiMD
Navigation: Wellness - Encyclopedia - Health topics - Disease Index‏‎ - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes

Search WikiMD

Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD

WikiMD's Wellness Encyclopedia

Let Food Be Thy Medicine
Medicine Thy Food - Hippocrates

WikiMD is not a substitute for professional medical advice. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.

Contributors: Prab R. Tumpati, MD