DSG3

DSG3 (Desmoglein 3) is a protein that in humans is encoded by the DSG3 gene. It is a member of the desmoglein family and cadherin cell adhesion molecule superfamily of proteins. DSG3 is found in the desmosome structures of epithelial cells, particularly those of the skin and mucous membranes.

Function

DSG3 plays a crucial role in the formation and maintenance of cell adhesion structures called desmosomes. These structures are found in epithelial cells, which line the surfaces and cavities of the body. Desmosomes provide strength to tissues by ensuring that cells are bound together. They are particularly important in areas of the body that experience a lot of friction and wear and tear, such as the skin and the lining of the mouth.

Clinical significance

Mutations in the DSG3 gene, as well as the presence of autoantibodies against DSG3, are associated with the autoimmune blistering disease pemphigus vulgaris. This condition is characterized by the formation of blisters in the skin and mucous membranes. In pemphigus vulgaris, the immune system mistakenly attacks the desmosomes, leading to a loss of cell adhesion and the formation of blisters.

See also

• Desmoglein
• Pemphigus vulgaris
• Desmosome
• Cadherin

External links

• DSG3 at the National Center for Biotechnology Information

DSG3 Resources
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