Desmoglein
Desmoglein is a protein in humans that is encoded by the DSG gene. Desmoglein is a component of desmosome structures in cells, which are involved in cell adhesion, signalling, and cell structure. There are four types of desmoglein: DSG1, DSG2, DSG3, and DSG4.
Function[edit | edit source]
Desmogleins are part of the cadherin protein family and are located on the cell surface. They play a crucial role in the formation of desmosomes, which are cell structures that help cells adhere to each other. Desmogleins also play a role in cell signalling and maintaining cell structure.
Clinical significance[edit | edit source]
Mutations in the DSG genes can lead to several skin and hair disorders. For example, mutations in DSG1 and DSG3 can cause pemphigus, a group of rare autoimmune blistering diseases. Mutations in DSG4 can cause hypotrichosis, a condition characterized by a decrease in the amount of hair on the scalp.
See also[edit | edit source]
References[edit | edit source]
Desmoglein Resources | ||
---|---|---|
|
|
Translate to: East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
Urdu,
বাংলা,
తెలుగు,
தமிழ்,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
European
español,
Deutsch,
français,
русский,
português do Brasil,
Italian,
polski
Navigation: Wellness - Encyclopedia - Health topics - Disease Index - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro) available.
Advertise on WikiMD
WikiMD is not a substitute for professional medical advice. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.Contributors: Admin, Prab R. Tumpati, MD