Desmoglein
Desmoglein is a protein in humans that is encoded by the DSG gene. Desmoglein is a component of desmosome structures in cells, which are involved in cell adhesion, signalling, and cell structure. There are four types of desmoglein: DSG1, DSG2, DSG3, and DSG4.
Function[edit | edit source]
Desmogleins are part of the cadherin protein family and are located on the cell surface. They play a crucial role in the formation of desmosomes, which are cell structures that help cells adhere to each other. Desmogleins also play a role in cell signalling and maintaining cell structure.
Clinical significance[edit | edit source]
Mutations in the DSG genes can lead to several skin and hair disorders. For example, mutations in DSG1 and DSG3 can cause pemphigus, a group of rare autoimmune blistering diseases. Mutations in DSG4 can cause hypotrichosis, a condition characterized by a decrease in the amount of hair on the scalp.
See also[edit | edit source]
References[edit | edit source]
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