DSM 5

DMH-2

DMH-2 is a chemical compound that acts as a selective antagonist of the type 1 bone morphogenetic protein receptor (BMPR1). It is primarily used in scientific research to study the role of BMP signaling in various biological processes.

Chemical Structure and Properties

DMH-2 is a small molecule with the chemical formula C₁₉H₁₆N₄O₂. It is characterized by its ability to inhibit the activity of BMPR1, which is a receptor involved in the bone morphogenetic protein (BMP) signaling pathway. This pathway is crucial for the regulation of bone and cartilage development, as well as other cellular processes.

Mechanism of Action

DMH-2 functions by binding to the BMPR1 receptor, thereby blocking the binding of BMP ligands. This inhibition prevents the activation of downstream signaling pathways that are normally triggered by BMPs. As a result, DMH-2 can be used to study the effects of reduced BMP signaling in various experimental models.

Applications in Research

DMH-2 is widely used in research to investigate the role of BMP signaling in:

• Bone and Cartilage Development: By inhibiting BMPR1, researchers can study how BMP signaling affects the growth and differentiation of bone and cartilage cells.
• Cancer Research: BMP signaling has been implicated in the progression of certain cancers. DMH-2 can be used to explore the potential therapeutic effects of BMP inhibition in cancer treatment.
• Stem Cell Differentiation: BMPs play a role in the differentiation of stem cells into various cell types. DMH-2 can help elucidate the pathways involved in stem cell fate decisions.

Safety and Handling

As with many research chemicals, DMH-2 should be handled with care. Appropriate safety measures, including the use of personal protective equipment (PPE) and working in a well-ventilated area, should be followed to minimize exposure risks.

Also see

• Bone Morphogenetic Protein
• Receptor Antagonist
• Signal Transduction
• Stem Cell Research