Danaparoid

Danaparoid is an anticoagulant medication that is used to prevent and treat thrombosis. It is a mixture of heparan sulfate, dermatan sulfate, and chondroitin sulfate, which are all glycosaminoglycans. Danaparoid is marketed under the brand name Orgaran.

Mechanism of Action[edit | edit source]

Danaparoid works by inhibiting factor Xa, a protein involved in blood clotting. It does this by enhancing the activity of antithrombin, a protein that inhibits factor Xa. This prevents the formation of blood clots.

Uses[edit | edit source]

Danaparoid is used to prevent and treat deep vein thrombosis (DVT) and pulmonary embolism (PE). It is also used in the treatment of heparin-induced thrombocytopenia (HIT).

Side Effects[edit | edit source]

Common side effects of danaparoid include bleeding, anemia, and thrombocytopenia. Rare but serious side effects include allergic reactions, osteoporosis, and heparin-induced thrombocytopenia (HIT).

Contraindications[edit | edit source]

Danaparoid should not be used in people with active bleeding or a history of heparin-induced thrombocytopenia (HIT). It should also not be used in people with severe kidney disease.

Interactions[edit | edit source]

Danaparoid may interact with other anticoagulants, increasing the risk of bleeding. It may also interact with certain medications used to treat heart disease and high blood pressure.

Dosage[edit | edit source]

The dosage of danaparoid depends on the condition being treated and the patient's weight. It is usually given as an injection under the skin.

See Also[edit | edit source]

Danaparoid Resources
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