Danaparoid sodium

Danaparoid Sodium is an anticoagulant medication that is primarily used in the prevention and treatment of thrombosis. It is a low molecular weight heparinoid, and is derived from porcine intestinal mucosa.

Mechanism of Action

Danaparoid Sodium works by inhibiting factor Xa, a key enzyme in the coagulation cascade. This inhibition prevents the formation of thrombin, thereby reducing the risk of clot formation. Unlike heparin, danaparoid sodium does not significantly inhibit thrombin directly, but enhances the inhibition of factor Xa by antithrombin III.

Clinical Uses

Danaparoid Sodium is used in the prevention and treatment of deep vein thrombosis and pulmonary embolism. It is also used in the management of heparin-induced thrombocytopenia (HIT), a condition in which the use of heparin leads to a decrease in platelets and an increased risk of thrombosis.

Side Effects

The most common side effect of Danaparoid Sodium is bleeding, which can be severe in some cases. Other side effects include thrombocytopenia, hypersensitivity reactions, and skin necrosis.

Contraindications

Danaparoid Sodium is contraindicated in patients with known hypersensitivity to the drug, in patients with severe renal impairment, and in those with active bleeding or a high risk of bleeding.

Drug Interactions

Danaparoid Sodium may interact with other anticoagulants, increasing the risk of bleeding. It may also interact with platelet inhibitors, thrombolytic agents, and certain other medications.

Dosage and Administration

The dosage of Danaparoid Sodium is individualized based on the patient's weight, the indication for use, and the patient's renal function. It is typically administered by subcutaneous injection.

See Also

• Anticoagulant
• Factor Xa
• Deep vein thrombosis
• Pulmonary embolism
• Heparin-induced thrombocytopenia