Danicopan

From WikiMD.com - Food, Medicine & Wellness Encyclopedia

Overview of the medication Danicopan


Danicopan
INN
Drug class
Routes of administration
Pregnancy category
Bioavailability
Metabolism
Elimination half-life
Excretion
Legal status
CAS Number
PubChem
DrugBank
ChemSpider
KEGG


Danicopan is an investigational oral medication that acts as a complement factor D inhibitor. It is primarily being studied for its potential use in treating paroxysmal nocturnal hemoglobinuria (PNH), a rare and life-threatening blood disorder.

Mechanism of Action[edit | edit source]

Danicopan works by inhibiting the activity of complement factor D, a serine protease that plays a crucial role in the activation of the alternative complement pathway. By blocking this pathway, Danicopan prevents the destruction of red blood cells, which is a hallmark of PNH. This mechanism helps to reduce hemolysis and improve the clinical symptoms associated with the disease.

Clinical Development[edit | edit source]

Danicopan is currently undergoing clinical trials to evaluate its safety and efficacy in patients with PNH. Early studies have shown promising results, with significant reductions in hemolysis markers and improvements in hemoglobin levels. The drug is being developed by Alexion Pharmaceuticals, a company known for its focus on rare diseases.

Potential Benefits[edit | edit source]

The use of Danicopan in PNH patients could offer several benefits, including:

  • Reduction in the need for blood transfusions
  • Improvement in quality of life
  • Decrease in the risk of thrombotic events

Side Effects[edit | edit source]

As with any medication, Danicopan may cause side effects. Commonly reported adverse effects include:

  • Headache
  • Nausea
  • Fatigue

Patients receiving Danicopan should be monitored for any signs of infection, as complement inhibition can increase susceptibility to certain infections.

Related pages[edit | edit source]

WikiMD
Navigation: Wellness - Encyclopedia - Health topics - Disease Index‏‎ - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes

Transform your life with W8MD's budget GLP1 injections from $125

W8mdlogo.png
W8MD weight loss doctors team

W8MD offers a medical weight loss program NYC and a clinic to lose weight in Philadelphia. Our W8MD's physician supervised medical weight loss centers in NYC provides expert medical guidance, and offers telemedicine options for convenience.

Why choose W8MD?

Book Your Appointment

Start your NYC weight loss journey today at our NYC medical weight loss, and Philadelphia medical weight loss Call (718)946-5500 for NY and 215 676 2334 for PA

Search WikiMD

Ad.Tired of being Overweight? Try W8MD's NYC physician weight loss.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available. Call 718 946 5500.
Advertise on WikiMD

WikiMD's Wellness Encyclopedia

Let Food Be Thy Medicine
Medicine Thy Food - Hippocrates

Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.

Contributors: Prab R. Tumpati, MD