Desmethyldoxepin

Desmethyldoxepin is a metabolite of the tricyclic antidepressant doxepin. It is formed in the body after the administration of doxepin, through the process of metabolism.

Chemistry

Desmethyldoxepin is a dibenzoxepin derivative. It is a tricyclic compound, with three rings in its chemical structure. The compound is also a secondary amine, meaning it contains a nitrogen atom with two substituents.

Pharmacology

Desmethyldoxepin has antidepressant and anxiolytic properties. It works by inhibiting the reuptake of serotonin and norepinephrine, two neurotransmitters that are involved in mood regulation. This increases the levels of these neurotransmitters in the brain, which can help to alleviate symptoms of depression and anxiety.

Desmethyldoxepin also has antihistamine effects, which can cause drowsiness. This makes it useful for treating conditions like insomnia.

Metabolism

Desmethyldoxepin is formed in the body through the process of metabolism. This involves the removal of a methyl group from doxepin, a process that is carried out by enzymes in the liver. The resulting compound, desmethyldoxepin, is then further metabolized to other compounds, or excreted from the body.

Side effects

Like other tricyclic antidepressants, desmethyldoxepin can cause a range of side effects. These can include drowsiness, dry mouth, blurred vision, constipation, and urinary retention. In rare cases, it can also cause more serious side effects like heart problems, seizures, and severe allergic reactions.

See also

• Doxepin
• Tricyclic antidepressant
• Metabolite