Desmethylmoramide
Desmethylmoramide is a synthetic opioid that is structurally related to methadone. It was developed in the 1960s as part of a series of opioid analgesics, but was never marketed. Desmethylmoramide has been studied in the context of its potential use in the treatment of opioid dependence.
Chemistry[edit | edit source]
Desmethylmoramide is a synthetic compound that belongs to the class of chemicals known as phenylpiperidines. It is structurally similar to methadone, with the primary difference being the absence of a methyl group on the nitrogen atom. This structural difference is believed to contribute to the differences in pharmacological activity observed between desmethylmoramide and methadone.
Pharmacology[edit | edit source]
Desmethylmoramide acts as an agonist at the mu-opioid receptor, which is the primary site of action for most opioid analgesics. It has been shown to have a higher affinity for the mu-opioid receptor than methadone, suggesting that it may have a higher potency. However, the clinical significance of this finding is unclear, as desmethylmoramide has never been used in humans.
Potential Therapeutic Uses[edit | edit source]
Desmethylmoramide has been studied for its potential use in the treatment of opioid dependence. In animal models, it has been shown to reduce opioid withdrawal symptoms and decrease self-administration of opioids. However, further research is needed to determine the safety and efficacy of desmethylmoramide in humans.
See Also[edit | edit source]
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