Desoxyfructo-serotonin

Desoxyfructo-serotonin (DFS) is a naturally occurring serotonin derivative found in the human body. It is a neurotransmitter that plays a crucial role in various bodily functions, including mood regulation, sleep, appetite, and digestion.

Structure and Function

DFS is structurally similar to serotonin, with the primary difference being the absence of a hydroxyl group. This structural difference allows DFS to cross the blood-brain barrier more easily than serotonin, potentially enhancing its effects on the brain.

In terms of function, DFS acts as a neurotransmitter, transmitting signals across neurons in the brain. It is involved in the regulation of mood, sleep, appetite, and digestion. Additionally, DFS has been implicated in various psychiatric disorders, including depression, anxiety, and schizophrenia.

Synthesis and Metabolism

DFS is synthesized in the body from the amino acid tryptophan. This process involves several enzymatic reactions, with the final step being the conversion of 5-hydroxytryptophan to DFS by the enzyme aromatic L-amino acid decarboxylase.

Once synthesized, DFS is metabolized by the enzyme monoamine oxidase (MAO), which breaks it down into 5-hydroxyindoleacetic acid (5-HIAA). This metabolite is then excreted in the urine.

Clinical Significance

Due to its role as a neurotransmitter, DFS has been studied in the context of various psychiatric disorders. Elevated levels of DFS have been found in patients with depression, anxiety, and schizophrenia, suggesting a potential role in the pathophysiology of these conditions.

Furthermore, DFS may have therapeutic potential. Some studies have suggested that DFS could be used as a treatment for depression and anxiety, although more research is needed to confirm these findings.

See Also

• Serotonin
• Neurotransmitter
• Depression
• Anxiety
• Schizophrenia