Destrin
Destrin[edit | edit source]
Destrin, also known as actin-depolymerizing factor (ADF), is a protein that plays a crucial role in the regulation of the actin cytoskeleton in eukaryotic cells. It is involved in the disassembly of actin filaments, which is essential for various cellular processes such as cell motility, cytokinesis, and cellular morphogenesis.
Structure[edit | edit source]
Destrin is a member of the ADF/cofilin family of proteins, which are characterized by their ability to bind to actin and modulate its dynamics. The protein consists of a single polypeptide chain that folds into a compact structure, allowing it to interact with actin filaments. The structure of destrin includes several key regions that are responsible for its actin-binding and depolymerizing activities.
Function[edit | edit source]
Destrin functions primarily by binding to ADP-bound actin filaments, promoting their disassembly. This activity is crucial for the turnover and remodeling of the actin cytoskeleton, which is necessary for cell movement and shape changes. Destrin's ability to sever actin filaments and increase the rate of actin monomer dissociation is vital for maintaining the dynamic nature of the cytoskeleton.
Regulation[edit | edit source]
The activity of destrin is regulated by several factors, including phosphorylation and interactions with other proteins. Phosphorylation of destrin can inhibit its actin-depolymerizing activity, thereby stabilizing actin filaments. Additionally, destrin can be regulated by phosphoinositides and other signaling molecules that modulate its interaction with actin.
Clinical Significance[edit | edit source]
Alterations in destrin function or expression have been implicated in various diseases. For example, dysregulation of actin dynamics due to abnormal destrin activity can contribute to cancer cell metastasis, as well as neurodegenerative diseases. Understanding the role of destrin in these conditions may provide insights into potential therapeutic targets.
Related Pages[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
