Destrin

Destrin (also known as DSTN) is a protein that in humans is encoded by the DSTN gene. It is a member of the actin-depolymerizing factor (ADF)/cofilin family. This family of proteins is responsible for enhancing the turnover rate of actin in the body, which is a critical process in cell motility.

Function

Destrin is an actin-binding protein that has a vital role in cell motility, division, and health. It is involved in the dynamic turnover and restructuring of the actin cytoskeleton, a critical process in cell motility. Destrin binds to F-actin (filamentous actin), and it severs actin filaments (a process called actin severing) and binds to actin monomers (a process called actin sequestering).

Structure

The DSTN gene is located on the q arm of chromosome 20 at position 11.21. The protein encoded by this gene is part of the ADF/cofilin family of proteins. It is approximately 19 kDa in size and composed of 166 amino acids. The protein has a similar structure to other members of the ADF/cofilin family, with an ADF-H domain that is responsible for actin binding.

Clinical significance

Mutations in the DSTN gene have been associated with various diseases. For example, a mutation in this gene has been linked to autosomal recessive congenital cataract, a condition characterized by clouding of the lens in the eye. Research is ongoing to understand the role of destrin in other diseases, such as cancer and neurodegenerative diseases.

See also

• Actin
• Cofilin
• Cell motility
• Chromosome 20