Dexamethasone acefurate
Dexamethasone acefurate is a glucocorticoid used in veterinary medicine to treat inflammatory conditions. It is a derivative of dexamethasone and is often used due to its longer-lasting effects compared to other glucocorticoids.
Pharmacology[edit | edit source]
Dexamethasone acefurate is a prodrug of dexamethasone, meaning it is metabolized into dexamethasone in the body. It has a high lipophilicity, which allows it to be stored in the adipose tissue and slowly released over time. This results in a longer duration of action compared to other glucocorticoids.
The primary mechanism of action of dexamethasone acefurate is the suppression of inflammation and the immune response. It does this by binding to the glucocorticoid receptor, which leads to changes in gene expression that reduce the production of inflammatory cytokines and other mediators of inflammation.
Uses[edit | edit source]
In veterinary medicine, dexamethasone acefurate is used to treat a variety of inflammatory conditions. These include dermatitis, otitis, and arthritis. It is also used in the treatment of allergies and autoimmune diseases.
Side Effects[edit | edit source]
As with other glucocorticoids, the use of dexamethasone acefurate can lead to a number of side effects. These include immunosuppression, which can increase the risk of infections, and Cushing's syndrome, which can cause a variety of symptoms including weight gain, thinning skin, and increased thirst and urination.
See Also[edit | edit source]
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