Dibekacin

Dibekacin is an aminoglycoside antibiotic that is used in the treatment of various types of bacterial infections. It is derived from the bacterium Micromonospora and is particularly effective against Gram-negative bacteria.

Mechanism of Action

Dibekacin works by binding to the 30S ribosomal subunit of the bacteria, which interferes with protein synthesis. This prevents the bacteria from growing and multiplying, thereby stopping the infection.

Uses

Dibekacin is used to treat a variety of bacterial infections, including those caused by Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa. It is also used in the treatment of sepsis, urinary tract infections, and respiratory tract infections.

Side Effects

Like other aminoglycoside antibiotics, dibekacin can cause a number of side effects. These include ototoxicity, which can lead to hearing loss, and nephrotoxicity, which can cause kidney damage. Other potential side effects include nausea, vomiting, and rash.

Contraindications

Dibekacin is contraindicated in patients with a known hypersensitivity to aminoglycoside antibiotics. It should also be used with caution in patients with pre-existing kidney disease or hearing loss.

See Also

• Aminoglycoside
• Antibiotic
• Bacterial Infections
• Protein Synthesis

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